Conjugation of β-Adrenergic Antagonist Alprenolol to Implantable Polymer-Aescin Matrices for Local Delivery
نویسندگان
چکیده
The sustained release of alprenolol, a β-adrenergic antagonist, could be beneficial for the treatment of various heart diseases while reducing the side effects resulting from its continuous use. The novel and branched copolymers uniquely composed of biodegradable components (lactide and glycolide) have been synthesized using natural and therapeutically-efficient β-aescin-initiator, and consequently characterized to determine their structures and physicochemical properties. The obtained matrices were not cytoand genotoxic towards bacterial luminescence, protozoan, and Salmonella typhimurium TA1535. The copolymers release the drug in vitro in a sustained manner and without burst release. The value of the drug released was strongly dependent on the copolymer composition and highly correlated with the hydrolytic matrices’ degradation results.
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